Mine is Sci-Fi with a strong female protagonist (though she is a bit awkward and shy in person, she is a force to be reckoned with online)... she's more than a bit of me, really, although I started writing it before I came out to myself.
Since then she and the story have, well, changed. After achieving a strong political position (and hopefully after the reader has adopted her as a sympathetic heroine), someone finds out about her trans status (she has been stealth for years) and threatens to out her, discrediting her in the process, when she is the lone voice keeping the public from outright panic and rioting.
The concept may limit the marketability, but it's the story that *I* need to write. We'll see if it gets published. 😉