This is a very difficult thing for people to understand and accept. And for what ever reason, gender and sexuality is threatening to many people.
Of the people I have recently told (I refuse to say "come out" to. I was not in a closet and prefer to not use gay culture terminology), I have gotten mixed, but mostly positive reactions. My older brother, whom I have always been very close with, was very supportive. But I expected this. He's a very smart man.. a professor, and an artist.
My closest male friend was also very supportive. We have known each other since the mid 80s. I wasn't sure how he was going to take the news, but he's also an open minded guy. He said he hates to think of me in distress, and if that brings me peace then it's a good thing. I think we got closer since telling him.
My other very close friend is a lesbian, and while I thought that would make this easier for her to accept, I also know that some of the LGB community don't seem to like us Ts. It seemed to take her a little longer to accept. She thinks I'm taking very big steps. We don't seem to talk as much now.

I got good reactions from a few other friends.
My ex wife on the other hand, is having a harder time with this. When I started making some changes to my appearance, like plucking my eyebrows, and wearing nail polish (and at this point it was black nail polish), she called me up one day and asked if I was going to announce (still not using that phrase!) that I was gay. lol That cracked me up. So I explained the whole thing, she had that epiphany, realizing that this all explained why she always said I reminded her of a girl, in that I'm sensitive and kind and my mannerisms, all things she was attracted to, and that she offered her support. I explained the whole process, and even joked that she could come to Mexico with me for my FFS (assuming I go to Dr. C). That made me feel good.
Then she went away for the Halloween weekend, and I had our daughter that weekend, and my band played a Halloween party. My costume was my profile photo (taken in the bathroom when I put my wig on). I used that photo that week on my regular (boy mode) FaceBook page, and that freaked her out! She went from supportive, to saying I lied to her all these years by not telling her, and was not gong to let me see our daughter, because I was going to traumatize her. <sigh> She's even taking me to court.

She's calmed down a bit since then, but still thinks this is more of a big deal than I do. I keep saying, "look, it's not going to happen over night, and I'm still the same person, but I'll look different" But her response is "BUT YOU ARE CHANGING YOUR GENDER!"

(<-- her face) Well, yes and no, only on the outside. I've been a girl my whole life... lol Why, oh why, is this so hard for people to accept?
I can only imagine what my band mates are going to say (although I think the drummer knows, since he asks me about trans issues some times... I think he's been reading my Facebook posts lol)
But, no one has thought I was crazy, or needed therapy.