I never had any issues when it came to drinking and HRT. Once I was on drugs like Quetiapine ( A generic version of Seroquel) and Alprazolam due to these strange panic/anxiety attacks that popped up out of nowhere, I found out the hard way that I couldn't drink anymore. I normally would just have a cocktail or two and it was rare when I did drink. But last 4th of July, I drank a large amount for me (these days). It was almost a fifth of various mixed drinks. Well, the next day was pretty damn scary. I KNEW it was due to the alcohol interacting with those meds because I had never, ever felt like this before. It's hard to describe, really, but it scared me off from touching a drop of booze after that. (Which I suppose is for the best anyway...ya know...health reasons and all that.)