In my short experience the biggest difference I have found is the availability of services from one area/city to another, whether it is social, medical, support etc.
That being said I there are places I couldn't see myself transitioning in more so than places I would prefer to live. I also happen to be living in Sydney which also happens to have the biggest population in Australia and also arguably the most diversity (although maybe not exactly where I am living now!

), so maybe I'm just lucky.

In fact after reading many posts from around the globe I would say that we Aussies are doing alright. We have laws, good healthcare and other than the ignorant redneck types (which I'm sure are everywhere anyway) most people I've come across are pretty alright.