I saw the Thursday my endocrinologist told me that after 5 years of tratement I had to have a problem at my receptors of estrogen. I probably received a low estrogen. I am 5 years androcur and estrogen pill in the beginning then maintenent gel.

Are there people like me resistant to estrogen and do you have a solution. Not possible to unlock these receptors.

thank you,

Laure

I would be very surprised if you had such a problem or if such a problem even exists. I'd suspect that you were/are probably not taking enough estrogen. That your doctor is unwilling to increase dose and as such, feeds you a story that is not true. I could be wrong but that is what it seems like from what you've stated. What are your estradiol levels? 

I have never heard to estrogen resistance, I suppose women born with CAIS (Complete Androgen Insensitivity Syndrome) have the opposite problem that is they are resistant to T, so I guess it is within the realm of possibility, but I certainly have my doubts as to what your doctor is telling you.

I would think if anything were preventing estrogen from being absorbed it would be something competing for those receptors like too much progesterone or something. I am not a doctor, but it does just seem a bit strange to me.

Progesterone doesn't bind to estrogen receptors so can't compete with estrogen but it is somewhat antiestrogenic in that it downregulates (reduces) estrogen receptors and increases conversion of estradiol to its weaker form estrone. But, I don't think she is taking progesterone, she didn't make any mention of it.

I just think she isn't taking enough. Perhaps, switch doctors?

Hello,

Thanks for your answers. Since one year i take oestrogen by gel with oestrodose and Androcur. I doesn't take progesterone because for my endocrinologist, no study proves that it is necessary.

The results of my blood are good, very low level and testo a normal level for the estrogen.

My endocinologue told me that it is useless to take too oestrogne because the body can absoder a precise amount depending on each. What do you think?

Laure





Edited for Dosages - DO NOT POST DOSAGES

Hi coralie 

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Hugs

V M

I'm under the impression you are French. If so, you can always send me a message privately. I speak perfect french.

As to not being able to absorb more estrogen and that "too much" is useless, it's not true at all. Facts contradict this...otherwise, why do womens' levels increase during pregnancy and affect so strongly the body? If it was useless, then why would the body ever produce more and more? I've noticed better breast growth at higher doses typically not prescribed to transwomen, but approved by my doctor and none at lower doses. So, the extra can make a difference.

I will cite you another example. Prostate cancer male patients. Why are VERY high doses of estrogen given to them if the extra is useless and could potentially carry more risks? Because those prescribing them the estrogen understand that the extra MAKES A DIFFERENCE and also understand that bio-identical estradiol unlike other forms is much less risky, especially considering that it is given non-orally.

As to the role of progesterone, who knows whether it makes a difference? But these studies make one wonder...

From Bull Assoc Anat (Nancy). 1995 Mar;79(244):23-7.

"These data indicate that the proliferative stimulus of the mammary lobule is more intense during the luteal phase of the normal cycle and may probably be due to a synergistic action between progesterone and estradiol."

Breast Cancer Res Treat. 1996;40(2):187-96.

"The breast tissue from women operated on in the luteal menstrual cycle phase (day 15-28 among oral contraceptive (OC) users) had significantly higher proliferative rate than breast tissue removed from women in the follicular phase (day 1-14) (p = 0.01)."

Breast Cancer Res. 2005;7(3):R306-13. Epub 2005 Feb 16.

Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle.

"However, the cell renewal index (CRI = PI/AI) was significantly higher in the luteal phase (P = 0.033)." 

Hi Coralie,

You asked the question, "What do I think?"

Answer. I think you need to change your Endocronoligist.

Huggs
Catherine 

I know that the effectiveness of testosterone is affected by a male's body fat levels. If their body fat increases too much, it's less effective, and it's more easily converted to estrogen. A similar thing may be true for estrogen (but I don't know). Estrogen may work better given a more ideal body fat level. I do know when women's body fat drops too low, bad things begin to occur, their periods can stop, etc.

I don't know if this could be a contributing cause, but it may be worth researching.

I agree with Nikko. Enough fat is needed for breast growth, for instance. Or curves, etc. Fat is also a tissue wherein there is an enzyme called aromatase which converts androgen to estrogen. But, in our case, contrary to genetic males or females that don't take exogenous hormones, we take estradiol so don't need to rely on our bodies for their production. But some fat helps with feminization, a minimum.

Thanks for you answer,

KayXo: I'am french but I can't send mail or reply by this forum. If i't possible, you can send me a mail to laure_lefebvre1975@hotmail.fr

For Nikko et Kayxo, about my fat, it's ok. I unfortunately took 15 kg. I made the mistake of taking the "and****" and eating the same quantities as before. Thank you business lunches!. Si i'm curve and try to do weightwatche to reduce my overweight and belly.

Hi Coralie

By virtue of you last post, you can now Private Message everyone. 15 is the magic number.

Huggs
Catherine