Bicalutamide is a strong anti-androgen and in my opinion, has less side-effects than Andro or Spiro. Is better tolerated. But, it doesn't reduce androgen, only blocks it. It also will not affect sex drive or spontaneous erections so that only estrogen will reduce it. Bicalutamide does not cross the blood brain barrier. I wouldn't advise taking as much as is prescribed to prostate cancer patients. You can take much less and it will still be effective. It's a very powerful drug. Half-life is also quite long (5-6 days) so it can be taken every 2-3 days.