After four years and nine months on E, my boobs still get sore from time to time, and sometimes it is associated with some growth coming on, or my bra had a wrinkle in it the day before and gave me a mild bruise, or other times it is sore for the pure spite of it it seems.
A year ago I had a suspicious mammogram and subsequent needle biopsy, and it was in and about an area that never had any pain at all in it!! Turned out it was totally benign firbrous tissue, but the moral of the story is, that just because it was sore did not make it suspicious, and just because it was not sore did not assure the doctor it was not suspicious.
If the soreness comes from a redness or swelling of your skin in the breasts or the site of a progesterone injection, or you have breathing problems, call the doctor immediately since that could be allergy issues. If there are no allergic reactions, and the tissue becomes really bothersome in other ways, also call the doctor.
During my first two years though the soreness varied from place to place and degree to degree. You had tissue coiled up in a tight little ball before E, and now it is inflating in a good number of directions.