My skin getting softer was one of my first noticeable effects. I didn't know how soft they were until I tried to open a bottle. I use to be able to open it without any problem at all, but now it bites into my flesh. I've been using a towel to cover it and protect my feminine hands!
I've always had very poor upper body strength and pickle jars were an effort to open. Now I can't open them at all! The was the first time I noticed my strength diminishing. I actually went online to look up how to open a pickle jar.

I ended up poking a hole in the lid which equalized the pressure. Then with a little bit of effort I got it off.