i've started on Estradiol last week, intramusclar injevtion, and after 4 days I felt soreness on my nipples. I thought its the effect of the E. I am happy. No changes on the physical part of the nipples tho

But, the soreness subside gradually and after 7 days I dont feel it that much anymore. Does it mean it has stop growing?. I plan to take my second Estradiol injection next Sunday, which is 10 days after my first Estradiol injection. What actually happened

It is normal. you will go through periods of soreness and itching, sometimes at the same time. Growth will be in spurts. Totally natural.

The soreness comes and goes but sensitivity increases dramatically within the week I found.
Physical changes do start early and you will notice them.

I'm on the happy pills so cant comment about injections.

Eventually they will grow enough and be sore most of the time.

Enjoy

Oh the pains of womanhood.

From what I gathered through studies and feedback from several transgirls, it is best to inject estradiol every 7 days (if it is estradiol valerate) and every 10-14 days if it is estradiol cypionate, to not experience the lows, as levels tend to really crash thereafter. This may also vary from one girl to another, metabolism, stress levels, etc. One girl would inject every 5 days while someone else would still be fine after 10 days. But, general rule is 7 for EV and 10-14 for EC, as far as I know.

I'm on Injectable Estradiol Valerate injection every other Friday my nipples started getting sore about the first week after I started an have been sore every since I have been on the E for over 10 momths . so it normal an soon you will start seeing the changes ..