Upon my very first dose of E, the sh*tstorm in my head that was driving me nuts finally subsided. I was always very emotional, but this wonderful lightness and sense of calm came over me. When I finally tanked my T and took the full dose of E, things really improved. Rage, anger, irritability, frustration- gone. It was like how I felt when I was a kid.
According to my therapist who has a PhD and has literally dissected transgender brains, when your brain is wired to run on a hormone that it isn't getting, you get depressed and irritable. This is what happens during menopause and andropause for cispeople. When a hormone receptor gets the wrong hormone or no hormone, you do not get the "reward" of endorphines and proper neurotransmitter levels. I wasn't surprised when in retrospect my dysphoria was mitigated every time I became overweight. Body fat helps convert T into E. Also, my dysphoria shot through the roof every time I lost all the weight and/or bulked up with muscle. Throw a little andropause into the mix, and my endogenous hormones went haywire. I'd alternate between being OK and crying in a fetal position. Also, alcohol increases estradiol levels and pot temporarily reduces testosterone levels. It's no wonder I went there. It's also no wonder that I liked hoppy beers the best. Hops contain phytoestrogens. Everything makes perfect sense now.
I've said it before and I'll say it again- you will pry my E from my cold, dead hand!