I can think of two issues that I have: one internal and one external.
Internal: We can't let go of the past. My non-trans example: When I was born, my other left me with my grandparents. My father remarried a woman who had children and she did not know what to do with this strange boy thing. MY father hated me, my step mother was weak and I had developmental difficulties. Then came abuse. I've had 28 major fractures and 11 major surgeries on bones. FFS was very complicated because of the at least 14 facial fractures that I don't include in that 28 number above. If I hold on to that, I will go crazy. I think everyone can agree with that. Everyone knows that. I'd be a bitter, angry, unpleasant broken human thing. I had to let go, to realize that if anything good was to come from this life, I had to be ready, not dwelling on the past. Being transgender is similar: If I sit around and morn over what was lost because of malformed genitals, life is over. I have not forgotten the past but it is mostly irrelevant on how I live today. I enjoy today and look forward to tomorrow.
External: The poor understanding or even hatred by others. My transgender example: I have come out to so many people and have had so many positive responses, it's unbelievable. Only my older lesbian step sister was negative. Unfortunately, I didn't realize how much. To keep me from transitioning, she started to call my wife (who was mostly OK) with horror stories of trans people and horror stories of living as a lesbian couple. My sister thought that if my wife threatened to leave, I would not transition. She does not understand that the choice for me is transition or die. As strong as I am, I cannot fight the dysphoria that has grown so terrible these past two years. So, my wife is missing from my life as of May 29. My partner, my lover and my best friend now only answers when I call her and is so very cold. I do not know how to fight hatred and that is what my sister had. I am not looking for condolances with this post. I only point out hatred exists.
Jen