So about a year ago I kicked smoking cigs, looking into the future benefits of stopping of course. 

My question is, does liquid nicotine have any adverse effects when on HRT?  Should I consider kicking the e-cig thing too? 

Ill need to find a new oral fixation, maybe tooth picks? 

I've been vaping for about 4 years, with no side effects other than my asthma is gonners. I even read somewhere that vaping has no risk of blood clots because it doesn't have the crazy inrush of nicotine like cigarettes.

OO kewl, good because... I love vaping haha.

They're talking about negative things for estrogen absorbtion in this thread
https://www.susans.org/forums/index.php/topic,167620.0.html

Nicotine is one of them...

Better switch to non-nicotine vapes then, I think its time anyways 

Nicotine in the blood does interact (negatively) with estrogen, IF and only IF taken orally.

I do the vaping thing too.  When I first went to start HRT my endo was pretty adamant that I stop smoking immediately, which I did, but I started using an e-cig to step down.  He seemed pretty happy with that when I had my last follow up but yeah after reading this I guess I need to step up my efforts to get down to a zero nicotine version....  Ugh....  Never ends....

Or you can just take your estrogen non-orally...

True....  don't injectables work better anyway?  Or at least they're better on the liver?

I'll have to ask my endo when I see him next.  He didn't seem concerned about the nicotine in cigarettes nearly as much as all of the other nasties that they contain.

Injectables worked better for me. Thromboembolic risks as they relate to liver production of clotting proteins/enzymes appear to be quite low on injectables but bio-identical estradiol taken orally also appears to confer less risks than say birth control pills or Premarin given to post-menopausal women.

Nicotine still negatively interacts with estrogen taken orally by reducing concentration of estradiol in the blood. In one study of which I have the full article, the levels of estradiol, when taken orally were 5 x lower in women who smoked 10-20 cigarettes daily vs non-smokers. Non-orally (patch), levels were similar, it didn't make a difference.

Wow, thank you for the information...  Yes, I definitely need to kick the nicotine altogether.  Stupid addiction anyway.

Speaking of addictions, I wish that endocrinologists would kick their addiction to prescribing oral HRT! If demand was higher for other methods, it would surely become cheaper and better for everyone.

Haha, maybe I can help with that trend during my next endo visit?  I'll definitely ask the question anyway. 

IDK why that is.  Maybe because anti-androgens are oral and it's just easier to keep everything the same?  At least mine are anyway, jeez...  So much to learn...

Non Nicotine vapes are just as good anyways, so many flavors.

Hi just kinda off topic to jenny and the other girl if your on orals I would HIGHLY recommend talking to your endro mine has been doing hrt for 30 yrs here in California he told me he won't even prescribe orals horrible for your liver and to get your levels at a good level your over stressing the liver since it has to process it I'm doing surgical pellets and am very happy they last 3-6 months and a consistent dose so no ups and downs anyway best of luck

Quote from: Jennygirl on June 23, 2014, 09:17:17 PM
Speaking of addictions, I wish that endocrinologists would kick their addiction to prescribing oral HRT! If demand was higher for other methods, it would surely become cheaper and better for everyone.

I agree. As I always tend to agree with you, LOL!

Quote from: AmazinglyAutumn on June 23, 2014, 09:38:36 PM
Maybe because anti-androgens are oral

Actually, cyproterone acetate can also be administered by injection as can LhRh agonists, through pellets and nasal sprays as well.

Quote from: Jessica90 on June 24, 2014, 12:33:50 AM
he won't even prescribe orals horrible for your liver

The bad rap about liver comes from birth control pills and all the other hormones that are NOT bio-identical such as Provera and Premarin. Bio-identical is quite another different ballgame and risks appear to be much lower. And it's important to make the difference between impact on liver health and clotting factors, the latter being much more significantly affected by estrogen, especially non-native.

But, I do agree that non-oral is a "cleaner", more effective means of getting your estrogen. I've been much better since injectables.

Quote from: Jessica90 on June 24, 2014, 12:33:50 AM
Hi just kinda off topic to jenny and the other girl if your on orals I would HIGHLY recommend talking to your endro mine has been doing hrt for 30 yrs here in California he told me he won't even prescribe orals horrible for your liver and to get your levels at a good level your over stressing the liver since it has to process it I'm doing surgical pellets and am very happy they last 3-6 months and a consistent dose so no ups and downs anyway best of luck

Sounds like we have the same endo maybe? I am in California as well. I've never put a single hormone / antiandrogen pill in my mouth and I never will.

Always happy to hear of another person using pellets- I wish I could convince everyone to go this route. You are very right about the consistency and happiness thing. Not to mention you pretty much forget you're on HRT at all

Feel like a bit of a dunce for needing this clarified, but does sublingual fall under oral?