Hi.. Welcome.. Sorry, I dont have any experience with beginning in your 40's.. I began when I was 54 tho. I started with herbals. The calming effect that I got from them.. well.. I would be a lot worse off if I hadn't. I switched recently, to a low/micro dose of script based HRT. Estrodiol, Spiro and Finesteride. Every 3-4days or so.. it's all that I will allow myself, to keep my family.
As for changes, if that is what you are questioning, while everyone is different, you might be noticing mood swings, more emotions, maybe some calming with the E, I had fat redistribution after a few months (was on the herbals for almost 8mos). Hips began to be noticeable, my butt got bigger, skin softer, hair.. well, lets not go there just yet.. boobage.. oh my.. I am .. I guess.. reeeeeally lucky my family (3 women in the house), has not taken real notice of these things! I call it being Situationally Unaware. Totally unobservant, or else, they just haven't said anything. I did not have moobs, but these are def noticeable, at least to me, and some of my girl friends. I have to wear darker t-shirts, baggier shirts just to get them to be hidden.. Size and shape are all determined by genetics.. yours will likely be like your mom/sisters/aunts (if any) and actual size, it's said its about a size smaller than your family.. so eh.. whatever they have, figure abt a cup or so smaller.
How long it will take? Is anybody's guess. Could be a week or less for growth to start, could be a month, a year.. no one but your body will actually know. But if you haven't started yet, I would suggest getting a baseline blood panel (full workup if you can) to see your starting point. You'll have to get one anyway from your endo.. so plan on that.
At 48u, your bones are set, so there wont be any widening of your hips, it'll only be fatty deposits that will make them bigger/wider. Your waist could thin out as fat redistributes around. Legs will reshape, your face too. Arms.. some said their feet got smaller/narrower.. again fat moving around.
That's just some of the things that'll happen. Um, I -hope- that's what you were getting at.. if not, then disregard all after Welcome!