In the end, talent trumps gossip. Talent and hardware earn respect, not gossip. And besides, isn't Jamie Lee Curtis intersex? We may never know, but it's no one else's business anyway, and who really cares?
Being discreet about who knows and who you discuss it with are the best you can do.
Be whatever you are and do what you're good at, and I think that eventually you'll find a way to stop thinking and worrying about it. Sure, the day might come when your darkest nightmare and biggest secret comes to light - Everyone knows! A gossip columnist, other professionals in your industry, who knows... Yes, that's a possibility, but afterwards it probably wouldn't be so bad as you think. If it was, you might have to find a different career, but many people have changed careers.
If you hanging around people who would kill you for that, I'd find a different crowd to hang with.
A post by someone here on this forum once remarked that it's too bad a TS's couldn't do something truly great, such as win a Nobel Price, or something. I think they wanted to say that we each have the potential to be shining examples of what we can be, not of what we are limited to by what we are. Don't remain focused on something that's going to impede your success in life, such as what other people might think or say.
As for the danger of being killed, yes, that's a really possibility for anyone in your situation, but it goes with the territory. If people who know you, and know, understand, they are less likely to make it public. There were plenty of famous actors who were gay, but never confirmed it, even though there were always these certain rumors...