I am 56. I am just 5 weeks in, on E in a pure form (estradiol valerate) and P in a pure form (micronized progesterone). I have spiro at my house, but I have taken any spiro yet and I don't want until and unless it becomes absolutely necessary.
I have what I consider to be spectacular results so far.
My nipples are protruding and very large and always erect. I have many white bumps all over my nipple and areola areas. My nipples appear ready for a baby to nurse on them. I am happier than happy!!!

My breasts are for sure more round and feminine now. I don't think they are a lot bigger yet, but yes a little bit, and my 6 year old daugher, for the first time ever, was staring at my breasts at the pool today, so SHE certainly notices the difference.
When I have a shirt on and it is medium tight against my chest area, my nipples are rather obvious now, poking through my shirt.
My former body odor problem totally disappeared within 3 weeks on hormones.
My facial acnes has almost totally disappeared.
My hair is now growing longer a bit, again...remember I am 56, and I have a little gray...but now my hair on my head is of higher quality, and softer. The difference is astrounding to me.
MOST important, I am stunned at the significant psychological changes.
I have almost constant happiness. I seem to be able to handle even major work problems and personal relationship issues with a much more INTUITIVE FEEL and I am absolutely stunned at how great this is.
So, can high-quality, medical grade female hormones work starting at age 56?
I think my answer is super obvious.
All the best (and breast!).
Johanna