No matter how you view something, you really can't control how another person will feel about it. Unfortunately, just being trans makes a lot of people uncomfortable.
You can be completely, 100% honest without revealing every little detail about yourself. Some things might be a need-to-know thing only. Maybe you'd be able to show them it's not a problem after they hired you. Legally, (if you're in the US or another country with the right laws), they can't discriminate because you're trans, but in reality all that does is stop them from saying that's the reason. It's a lot easier to show them it's really not that big a deal after you've been hired.
In way less cynical words, this is a lot like interviewing for a job, let's say hypothetically as a car mechanic or something, and you say in the interview you're passionate about football. Maybe you really love football, but it's not relevant to the job at all. Your passion might put them off, just because you're talking to them about something that has absolutely nothing to do with fixing cars. In an interview or a resume, you really want to focus on the job, and just the job. Everything else can come later, after you're already employed by them.
That's my opinion, anyway. Maybe other people might feel differently, and maybe I'm wrong.