I take my hormones exactly 12 hours apart daily. Literally 8:30 AM, and 8:30 PM. It works wonders for me. Anyways, the other day I took it at 10 AM. By the following day my skin was rough, and my pores were bigger. I immediately began taking it on time, I got a facial and neck massage, and my skin is again baby like. It had to be the hormones, I made no other changes!