I had hot flashes and anxiety attacks when I had my dosage increased. But my current Endo thinks that the anxiety attacks were triggered by something else. Once I went back to my normal dosage, the hot flashes went away, but the anxiety attacks remained. After a year and a half of tests, they couldn't find a cause for the anxiety attacks (that came out of nowhere) and I've been taking a couple of medications to combat them. This has been the only thing that has worked as far as those were concerned.