I will likely be on anti-depressants for the rest of my life. Since the alternative is death, it's a good trade.
Same with HRT...for me, testosterone is poisonous...I had to get rid of as much as I could, via Spiro (which will stop once I get either an orchi or SRS), but one does need some form of hormone, and for me it's Estrogen...but since I don't have OEM ovaries, I have to do the pill thing.
Which is completely fine by me.