Hmmmm Obvious questions first. DIY or medically supervised? If the latter, what did the doc say?
The type of estrogen (conjugated vs synthetic) and the delivery route (pills, patches, shots, implants) all are up for grabs. (or YMMV) None of the women in my TG group ever stopped at one. Plus, as I personally found out, the source of the E, in the case of shots, made a BIG difference. Domestic vs India/SEA. Domestic FAR better

, almost like the first time
Too high of an E level is actually counterproductive. Perhaps that explains why so many endos like an E2 reading of around 200 pg/ml. Though I've also seen many gender center clients report that all the doc seemed interested in was T level and physical results. I know w/o an AA my T will creep back up to lowish normal male. Probably totally normal for a 58 y/o dinosaur. My E was around 300 a couple of days after a shot.
As an old timer in the TS world I know in eons past that many women reported better results mimicking a normal womans cycle of 3 weeks on E and then off a week, or taking Provera. Not sure what the current literature says. As said elsewhere, check with the doc
BTW - I was just reading elsewhere in a medical book that bouncing boobies or massaging is actually true. I know since HRT I often take the stairs rather then the lift