For me, it manifests as fluid (lymph) retention in the calves, ankles and feet. It first appeared when I was 12 (around the time I got my first period), and I spent years going back and forth with doctors and tests to figure out what was the root cause. No diabetes. No vessel blockages or other issues. Eventually, we determined that I had some food sensitivities, and the systemic reaction was causing the swelling to flare up. So I have been able to keep it in check for years with diet (including avoiding the trigger foods, low sodium intake, and lots of water), compression, and exercise. But it started flaring up a few weeks after starting T.