I had to stop for GRS, and I had some hot flashes and general crankiness, but other than that it's hard to say - I was stressed out and over-emotional, but that would've happened anyway given what I was waiting for.
Overall, though it wasn't pleasant, it was temporary.
It also may be possible to get permission to continue antidepressants during the "no meds period" - I know of several women who have.