(It's entirely possible I could be wrong about any of the following)
Spironolactone is a diuretic, meaning it causes you to pass liquids faster than you would normally. As long as you don't drink anything between 30 minutes to an hour before you go to sleep, you probably won't have any issues with needing to get up to urinate during the night.
For hormones, I'm relatively sure it's important to keep a fixed schedule, at fixed times. The set schedule will help your body adapt to it faster, and theoretically make it more effective. Breaking the dose into morning and night doses helps keep a higher constant dose for the day. And sublingual administration helps with absorption, skipping the liver in the first metabolic process.
Hugs,
- Katie
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