The best advice I can probably give is for her to start seeing a therapist who specializes in dealing with transgender patients. They could probably help her a lot more than I can from just seeing this little snippet.
It can be a difficult road, but she can make it. Please reassure her that things are going to turn out okay, that she's beautiful, and that she can transition successfully and be happy. And sometimes parents do come around in time, if they aren't initially accepting. I don't know what sort of job she has, so I can't speak to how friendly her work environment might be, but colleges are generally pretty accepting of trans people.