Just one? Are you kidding? Can't be done.
For Sci-fi it's War of the Worlds, I also love Steps of the sun where a billionaire buys a space ship to hunt for safe uranium to save the world from rapidly diminishing fuel sources, he ends up staying on a planet all alone like an outer space hermit.
For fantasy/comedy it has to be Monstrous Regiment by Terry Pratchett, a girl joins the army to search for her missing brother, the catch? No girls allowed. I think all trans people should find this book side splitting, I know I did.
I'll give you a taster to whet your appetite:
(To set the scene, Polly is trying to walk like a man)
Let's see, now....arms out from the body as though holding a couple of bags of flour.... Check. Shoulders swaying as though elbowing her way through a crowd....check. Hands slightly bunched and making rhythmical circular motions as though turning two independent handles attached to the waist...check. Legs moving forward loosely and ape like...check...
It worked fine for a few yards until she got something wrong and the resultant muscular confusion somersaulted her into a holly bush. After that, she gave up.
As Pratchett says "it's all in the socks"