Is just strange I think because low dose Climara would deliver the estradiol right into the blood and since the dose is low, there would be very little going through the liver. Also, if such low levels of estradiol were harmful to the liver, then all ciswomen around the globe (or, at the very least, many of them, given individual differences) should be suffering liver complications. I'm not a doctor but it seems to me, based on common sense, that liver complications were caused by something entirely different.