It's been a lovely 2 years since I've come out to family and friends, and "lovely" is the opposite of what I actually mean.
I have lost friends left and right for being me, and out of (say about 20 close friends) I only have 6 left. It has definitely put a major strain on my relationship with who is left, as before my transition we shared the same "friend-pool" and now things just get awkward anytime I'm brought into the equation.
As for my family, they were my real best friends. (I'm 1 of 12, being the middle child.) Only 2 sisters actively support me, and the rest either turn their "undisturbed" ear to me, or they've went out of their way to tell me how wrong it is what I'm doing. My mother started out telling me I had a mental disease and I could not be her daughter, but now has turned around A LOT and tells me she's glad I came out, and that she was sorry that she didn't see the daughter she always had but couldn't admit it. Now my dad is the opposite...in the way that in initially accepting his "son" become his daughter, he learned a few things about who I really am and was proactive for the first month of my outing. It only got worse and worse and to this day I know it isn't getting any better almost 2 years later. He (currently) dismisses any concerns I have about my safety, or requests for his advice, and even any mention of being his daughter as being "part of the hormones" or "You're just being paranoid". I can't mention anything related to transition, because the answer to it is: "I don't want to hear it."
Look at me rant! Sorry if I went off topic! TL:DR, I've lost a few of the "good ones", and it's been a tough journey so far.