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transdermal less effective than oral estrogen?

Started by JessicaAlba, October 16, 2015, 11:33:49 PM

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Isabelle

Quote from: iKate on October 17, 2015, 07:40:29 AM
Pills have to pass through the digestive tract and liver, which is why they are less effective than injections. If you take them sublingual however they bypass the liver.

Yes dear, that's taken into account when the dose is designed. The method of delivery doesn't matter, so long as the dose is therapeutic and safe. Certain methods are safer than others in certain situations. That's why differing delivery methods have been developed. So a therapeutic dose can be administered while keeping the side effects risks/benefits ratio within an acceptable level
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KayXo

Quote from: Joi on October 17, 2015, 06:43:51 PM
Between 1997 & 2002, I was on a low dose Estradiol pill with no andro blockers.   I was 50 yrs old at the time.  I experienced fairly rapid changes (breast budding, skin changes and fat re-distribution + emotional changes i.e. tearful reactions to simple things like a sad movie).  Fast forward to 2015,  started Xsex hormone therapy in early March.  this time Spiro, Medroxyprogesterone, Estradiol Patches.  After 90 days T levels off the chart low, E levels only 31. At 150 days & new labs, T-levels still below 1.0,  E level 42.  My endo dbld my E patches. So far: some breast tenderness, but little noticeable growth, skin dryness, and some softening.  No emotional reactions at all.  ????  Will test again in Nov.  My endo said he wanted to see my E level at or below 200.  I'm older now and have been told not to expect much at age 67.  Sure would like to see something movement at least above 100, but it's wait and see for now.

Perhaps, you aren't seeing changes because your estrogen dose is too low? Or the progestin, medroxyprogesterone acetate, is opposing it too strongly? I'm surprised your doctor prescribed you this progestin as it has shown to increase risk of clotting, cardiovascular complications, breast cancer and sometimes cause depression in some. It also has androgenic effects. Perhaps suggest bio-identical progesterone to your doctor instead which has, according to several studies, none of these side-effects?

I'm not telling you what to do, I'm not a doctor but instead, I'm suggesting that you share these with your doctor and see what they have to say. Working together, as doctor and informed patient, is always best, in my book, at least. :)

I've known women your age and older develop quite nicely. ;)
I am not a medical doctor, nor a scientist - opinions expressed by me on the subject of HRT are merely based on my own review of some of the scientific literature over the last decade or so, on anecdotal evidence from women in various discussion forums that I have come across, and my personal experience

On HRT since early 2004
Post-op since late 2005
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Madelyn Leech

I've been on pills for 3.5 months, they work really well for me. I haven't really had any side effects yet.
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Roberta W

I know you already have many, many replies here ... But what the heck!  I've used both pills and patches.  I believe there is a tell-tale sign when either is working, and that is the tenderness of your nipples.  If one method or the other gives you more or less sensitivity there, then you know something.  For me the pills and the patches both delivered about the same degree of tenderness ...
It took a lot of doing, but I take a lot of pride in what I am.
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