It took 2 years if I'm honest, before hrt really started changing my body, sure I had grown breasts and what not, but I wasn't until the stuff had really sat in my body that I started to see the difference. Me andy wife will be trying to get pregnant in the coming months which means no hormones for a while, from everything I have read, everything returns to prevent hrt pretty quickly, as far as levels, but would take months to reverse long term body changes, so a few days or weeks off not a big deal.