This might sound incredibly stupid, but I'm going to ask this anyway.
Does local anesthesia have any effect on estradiol levels, or even it's effectiveness? As well as anti-androgens? Say you have some form of surgery that allows for only local anesthesia, and then you are allowed to take your estradiol and anti-androgens. For the while that the anesthesia is in your system, does that take away any benefit from taking HRT?