Hi y'all, haven't been on here in a while!

I started Leuprolide injections over a month ago, and felt super crummy the first couple weeks. Then I started to feel amazing! While on HRT and being mindful of any changes in my regimen over the last 9 months I realize that Testosterone is what makes me feel awful. This has made me curious if any of y'all know of any studies that show biological evidence of why testosterone might make you feel terrible? Thanks!

I don't know but I had exactly the same experience.  Mine was way above average before and HRT dropped it by 700% so far.

I feel great which given the great emphasis I see today on men fixing low T to feel better definitely puts me outside that category.

Emotionally I have never felt better although I have noticed a decline in overall cardiovascular capability.  It's a small price to pay though.

I haven't looked at any studies but here's a thought. If the brain is female I would think you would feel horrible on T?

I guess this is kind of reverent I don't have the source handy at the moment so don't quote me! But some men take estradiol I believe to lessen the risk of prostate cancer and they react very negatively to it. Since a CIS male has a male brain and the brain says hey what's going on!

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Thanks! I feel pretty comfortable believing my brain is female so T interacts badly, but what is ACTUALLY happening chemically? The only thing I have found recently is the Williams Institute study that showed a difference in the allele for Androgen receptors for trans women as compared to cis men. I was curious if anyone knew what the actual interactions were that would cause negative feelings as compared to positive feelings or if there were any more recent studies performed that you know of.

If anyone knows the answer I would like to know too.  I have always heard the talk of male and female brains reacting badly to the opposite hormone but that always seemed to me to be mostly here-say and urban legend without any objective backing.

I can't cite the actual study, I will go look it up after I post this. But it was recently found that female brains have a large number of estrogen receptors and male brains have a large number of testosterone receptors. That's why hrt works. Mtf brains were being flooded with a hormone that it didn't know what to do with. Hrt fixes that and our brains are no longer deprived.

This is where I first came across some evidence. Ps I love this site...


http://www.avitale.com/TNote15Testosterone.htm

Mods:  if I shouldn't have posted this link please feel free to take it down

I had the same experience. As soon as i started blocking T, i started feeling better. When i added estrogen it got even better. I feel better now then i did 10-15 yrs ago, younger more energy, more focused.

Which is sort of funny because testosterone is supposed to be one of those energy important substances.

Quote from: Deborah on November 25, 2015, 09:36:31 AM
I don't know but I had exactly the same experience.  Mine was way above average before and HRT dropped it by 700% so far.

I feel great which given the great emphasis I see today on men fixing low T to feel better definitely puts me outside that category.

Emotionally I have never felt better although I have noticed a decline in overall cardiovascular capability.  It's a small price to pay though.

A year ago I had a flu that took me 10 days to get over and afterwards I experienced a decline in sex drive. I got my T tested and it was 160 which is low. It really hasn't gotten better and my doctor seemed nonplused. It hAs mellowed me out and I've become more loving, but my wife misses the old me. I have to wonder what bug I caught. Even my testicles aren't as big as they used to be.


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