Hello Dear,
I have posted elsewhere about this, but it is certainly no problem to repeat my personal experience. I was started on a T-blocker (spironolactone) and a DHT blocker (finasteride) several weeks before I started estradiol patches. I didn't feel any different on the spiro and finasteride.
The estradiol was a different story. Within several days, my dysphoria started to decrease. My appointments with my endocrinologists started out at every six weeks, at which time he would increase the spiro and estradiol doses. My libido vanished, and I started to get some mild pains around my nipples. I have since developed breast nodules, fuller breasts, and of course, constant breast pain. That took about three months.
I have also started to pack on the pounds, gaining about 7 pounds in the last month, despite decreasing my alcohol consumption significantly, and doubling my exercise regimen. I have decided to back off the estradiol until I see my endo next month. I was up to two patches at once, twice a week. I am going back to one patch at a time. Weight loss is now a priority for me.
The last caveat is that I am no doubt much older than you, so your experience may differ considerably. (Why do so few people list their age in their profiles???)
Hope that helps.
With kindness,
Terri