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Medical Effects/Complications of T

Started by Dar, December 28, 2015, 08:05:28 PM

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WorkingOnThomas

I'm at high risk for breast and ovarian cancer as things are, so it could be that I will further increase that risk with T. However, the studies are inconclusive, having read what little there is that actually exists covering transmen in particular. Furthermore, in the end, I'm going to have my, heh, excess organs removed. Which will lower the risk. Plus, there's the net benefit of not being absolutely miserable for the rest of life, however long that may be.
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Tysilio

Quote from: ...when you do not understand the science behind why they are very much so related.

And you make this assumption why? I'm fairly well qualified to read and evaluate scientific research, as it happens. I used to be on the faculty of a medical school and did research in biomedical science for a good many years, and I currently work as a pre-submission editor of scientific articles.

Shorn of big words like "sterols" and "phospholipid membranes," your point adds up to "hormones affect cellular function and sometimes that's a bad thing." That's trivially true, but it's irrelevant for the purpose of this discussion, which is specifically about the risks which come with testosterone therapy for trans men.

It's the consensus of the experts in the field that for most of us, the benefits far outweigh the potential risks. The WPATH standards go into some detail on this: there are contraindications for HRT, but cancer risk isn't one of them.

Never bring an umbrella to a coyote fight.
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RaptorChops

You can get cancer from just about anything these days.
¯\_(ツ)_/¯ I dunno.
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space.cowboy261

#23
Tysilio


I'm sorry that you don't understand the connection. My sentences were written hastily and fast. Saying what I said is "trivially true" is completely incorrect and un-ethical as a scientist for you to say.

I am doing my ethical duty to my beloved fellow humans by thoroughly explaining the risks, which I am disappointed in you as a fellow scientist not doing so thoroughly.

I tried to use the least amount of scientific words possible to get my point across, honestly. You just refuted me so I backed up what I said with facts. I don't want to sound rude, but if you don't know much about phospholipid membranes, how are you doing biomedical research?

These are words we use everyday. Since you are scientist I do not know why you are not understanding me? Maybe you do not have a background in physiology or chemistry background at all? Even my gf who is a nuclear engineer had to take physiology courses and organic chem to do biomedical research. She understands the risks involved with hrt because she had such great organic chemistry and physiology courses.

That's not the only scientific reason for risk evaluation. There are other reasons why that hormone replacement therapy or taking any medication long term is risky. We talked about these risks in my Organic Chemistry course, which I would think you have taken if you are doing biomedical research? We also discussed other possible ways for cancer to happen via fat soluble hormones in my physiology course.

The risk of medicines due to their variance in molecular shape between molecules that look very much the same but are not even though they have the same molecular formula.  (I won't say what they are called at risk of using any more big words) These different molecules will all be in one dose of the medicine, but only one of the molecular shapes is needed by the body even though maybe half the bottle is made up of that same formula in a different shape molecule. There is usually many different unneeded versions of the molecule in the medicine. (It's hard to extract completely pure medicine believe me we did this a lot in lab it is tough)

Now we go back to my previous posts where I talked about the ability of hormones to pass through membranes because they are fat soluble. The hormones have to go into the nucleus to print new proteins or other wise taking testosterone would have zero effect so it has to enter the nucleus where your dna is. This is where cancer can happen. Think about what a tumor is. a mass of tons of cells that were "printed" randomly and badly because somewhere the DNA got messed up.

Now you have all these different molecules entering the nucleus because no medicine is pure (even good quality medicine it's just too expensive) effecting your dna and your body has to try to deal with all of it. You do have natural ways of taking care of unwanted molecules. We as humans naturally fight pathogens and cancer, but one body can only take so much. It has to get rid of the molecules it doesn't need or which takes up a lot of your bodies natural defenses and leaves your immune system vulnerable. Those extra molecules don't just disappear, they must be dealt with and they are most certainly not all friendly. you also run the risk of one of the odd shapes running into a receptor that maybe only you have (just like allergies) and turning on or off a gene that doesn't need to be messed with and bam, cancer.

And for the millionth time, I didn't say ppl shouldn't do hormone therapy at all. Everyone should have the option. I just want people to realize the risk and look for a better way, we could be so close to finding a permanent solution. I've watched so many people suffer horrendously from cancer. It's literally a living hell, and it's also a living hell watching loved ones suffer until the end. It made me change my lifestyle. Again I know this doesn't matter to some people. I'm just trying to help people just like me.

Mod Edit- taking offense and attacking a user is against TOS 15.
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space.cowboy261

@Raptorchops

It doesn't have to be that way man. More than 90% of the time it's the environment (and i don't just mean pollution I mean diet and exercise smoking etc) Literally. Check the MDAnderson cancer website for my statistics.
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Mariah

 :police:
Okay Folks. Lets please be respectful of each other and don't attack others when we are posting. Thanks
Mariah

Quote15. Items under discussion shall be confined to the subject matter at hand. Members shall avoid taking the other users posts personally, and/or posting anything that can reasonably be construed as a personal attack.
If you have any questions, please feel free to ask me.
[email]mariahsusans.orgstaff@yahoo.com[/email]
I am also spouse of a transgender person.
Retired News Administrator
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Alexthecat

I think the point that everyone who is against you is trying to make is we are not scientists and don't really give a crap exactly what happens on the molecular level. Everyone knows the risks of T and the benefits before they are allowed to take it.

We can not take T and be miserable or take T and be happy. Cancer is an afterthought that isn't even guaranteed to happen.

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Moneyless

I was told by my doctors that the cancer risk with T is only significantly risen with female cancers, such as ovarian, cervical etc, which I wasn't too worried about as due to that I plan to get them removed. And that all other increased risk of cancers just come with the increased risk that males have for some cancers. Is this true?
started T 12/04/16 - 18 years old
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FTMax

Quote from: Moneyless on February 16, 2016, 04:07:44 AM
I was told by my doctors that the cancer risk with T is only significantly risen with female cancers, such as ovarian, cervical etc, which I wasn't too worried about as due to that I plan to get them removed. And that all other increased risk of cancers just come with the increased risk that males have for some cancers. Is this true?

Yes.
T: 12/5/2014 | Top: 4/21/2015 | Hysto: 2/6/2016 | Meta: 3/21/2017

I don't come here anymore, so if you need to get in touch send an email: maxdoeswork AT protonmail.com
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