Like said, in your case it is most likely genetic. I have a friend like you who has ripped 16.5 inch calves ( if not 17.5) .. they are looking so good... for a men. Back when i was doing bodybuilding i was training so hard to have calves like that and i was looking at him doing nothing and just having them... lol
HRT will help, make sure your T level is low enough. Some womans are gaining mass easier when they train because standard level for T for woman is between 0.4 and 3 and for a men its from like 12 to 35 i think. If a woman is close to 3, she will have easier time to gain muscle then one at 0.4. I am personally on HRT for 3.5 month with androcur and on my 2.5 month bloodtest my T had gone from 14 to 0.87 . Even if i would train like crazy i wouldnt gain anything.
I was doing bodybuilding for 6 years before starting hrt. I went from a 5.6 ft 128 lbs to 5.8ft ripped 178 lbs at 5% bodyfat. I had 17.5 inch biceps, 15.5 inch calves, 15 inch neck and 42 inch chest just to name a few.
Before starting HRT , i did cut my protein/calories intake, stopped mass training and only kept doing legs / cardio and i went down to 148 lbs 5.6ft at 8% bodyfat. Yep i lost 32 lbs pre-HRT of pure muscle mass over a period of 4-5 month so this is possible.
I am currently 153 lbs at 21.5% bodyfat at 3.5 month on HRT .
My biceps are now 12.5 inch rest and 13-13.5 inch flex .
My forearm is down to 10.5 inch
my Calves are down to 13.5 inch
my chest went from 42 inch to 34 inch then back to 37 with breast tissue
my neck went down to 13.5 inch
and this is only the begining, its perfectly possible but your calves will always give you hard time.