Quote from: Valwen on February 27, 2016, 01:08:02 AMSo my first session I had a physical, and blood work, I had to go back two weeks later and start medication for my blood pressure, then two weeks after that we added more blood pressure meds, and a few weeks after that my numbers looked good and I was able to sign the forms and start HRT.
Spironolactone, a commonly used anti-androgen in the US for transwomen actually LOWERS blood pressure, it's antihypertensive due to its antimineralocorticoid actions.
Bio-identical estradiol does not adversely affect blood pressure and can even have a beneficial effect as it is a vasodilator. Older forms of estrogens (not bio-identical) did have an adverse effect because of their significant effect on the renin-angiotensin system. Bio-identical progesterone can also have a positive effect in those with high blood pressure. Similar to spironolactone, it exerts antimineralocorticoid effects.
Hence, the right HRT may actually improve blood pressure or at worst, have a neutral effect. High blood pressure wouldn't appear to be a contraindication to HRT if the HRT used is adequate.
Here, just a few studies:
Ann Clin Res. 1983;15 Suppl 38:1-121. (oral estradiol was used)
"Estradiol-17 beta substitution decreased the systolic and diastolic blood pressure in normotensive, hypertensive and borderline hypertensive postmenopausal women."
"Irrespective of the pretreatment blood pressure levels, heart rate decreased during estradiol-17 beta substitution"
"Cardiac output increased in the normotensive test subjects but decreased in the hypertensive and borderline hypertensive subjects"
"Estradiol-17 beta substitution decreased the systolic and diastolic blood pressure in normotensive, hypertensive and borderline hypertensive postmenopausal women. The blood pressure of the hypertensive subjects decreased on average more than the blood pressure of the normotensive subjects."
Biochem Pharmacol. 2013 Dec 15;86(12):1627-42."Experimental studies supported vascular benefits of estrogen. Acute administration of estrogen in female or male patients improves vasodilator responses and ameliorates myocardial ischemia [4]."
"Estrogen also enhances the release of vasodilator substances such as nitric oxide (NO) and prostacyclin (PGI2), and decreases the production and effects of vasoconstrictors such as endothelin (ET-1) and angiotensin II (AngII) [1,2]."
Lancet. 1993 Jul 17;342(8864):133-6."Acute administration of oestradiol-17 beta therefore has a beneficial effect on myocardial ischaemia in women with coronary artery disease. This effect may be due to a direct coronary-relaxing effect, to peripheral vasodilation, or to a combination of these mechanisms. Oestradiol-17 beta may prove to be a useful adjunct to the treatment of angina in postmenopausal women with coronary heart disease."
Maturitas. 2008 Jul-Aug;60(3-4):185-201."recent indications suggest potential advantages for blood pressure control with non-oral estrogens"
"Recent evidence indeed shows that natural progesterone displays a favorable action on the vessels"
Horm Mol Biol Clin Investig. 2014 May;18(2):89-103."The cardiovascular protection observed in females has been attributed to the beneficial effects of estrogen on endothelial function."
"estrogen alone or combined with progesterone has been associated with decreased blood pressure"
"Estrogens physiologically stimulate the release of endothelium-derived vasodilator factors and inhibit the renin-angiotensin system."
Climacteric. 2012 Apr;15 Suppl 1:11-7. "Micronized progesterone has a neutral effect on the vasculature, including a neutral or beneficial effect on blood pressure."
Climacteric. 2013 Aug;16 Suppl 1:44-53."The addition of micronized progesterone to CEE has been reported to abolish the increased daytime blood pressure of normotensive women and potentiate the CEE-related decreased daytime systolic blood pressure in hypertensive women26."
CEE= conjugated equine estrogens (older form of estrogen; not good)
Endocrine Reviews, April 2013, 34(2):171–208"Interestingly, no changes were observed in blood pressure with progesterone administration
to normotensive postmenopausal women, although
a slight reduction in blood pressure was observed in hypertensive women (198)."
QuoteAside from the physial and blood work from my first visit to make sure I was healthy enough to start something that taxes your body
The right HRT is beneficial to your body, reduces risk of atherosclorosis and CVD (cardiovascular disease), improves blood pressure, etc. This idea that female hormones and HRT is taxing comes from decades ago when the wrong forms of hormones/drugs were used. Ciswomen fare better than men, live longer and are exposed to the same hormones we take for decades, sometimes in very high levels (during pregnancy).