I've always easily made friends with cisguys straight and gay, but I'd guess maybe a quarter of straight guys get awkward when I tell them I'm trans. Half of cisguys and cisgirls visibly treat me like "less of a man" at least temporarily. A very tiny percentage get angry. I've had a range of reactions, some of them really weird.
I'm a white guy in my mid thirties in Portland Oregon, for context. And a lot of the adults I talk to are teachers, therapists, skills trainers, aides, and other parents. Of those categories only therapists are known for being chill with transgender people.