Hormones and emotions, I believe that books have been written on the topic, and way too many jokes! I just began my third month on beginning levels of Estradiol and mid range levels of Spriro and have yet to get blood test data back. My first month was very intense and exciting, starting to actively pursue the changes that I has wanted for so long, but little of what I could call "emotional meltdowns". Month two signaled a big change in that regard. I have never cried so much in all of my life, over significant things and also over things of no significance at all (and quite embarrassing at times). I will go a week with no tears and then pour out a few thousand of them for the next week. And I wouldn't give them up for anything! - Anne