I take spiro along with estrogen I take estrogen morning and night but only take spiro in morning. I feel like my feminization has stayed the same for a long time now I've only been on hormones for alittle over a year. Do you think spiro should be split up or it doesn't matter? Or maybe my hormone levels aren't at proper levels I don't know. Has anyone experienced their feminization at a stand still just staying the same? I was thinking maybe because I should split my spiro

Do you have blood test results?

Quote from: transnztal on October 05, 2016, 07:35:29 PM
Or maybe my hormone levels aren't at proper levels I don't know.

I hope you are getting your blood tested regularly as part of the care you are receiving from your health care provider, in addition to the HRT itself.  The lab test results should tell you if your testosterone and estrogen levels are at the appropriate levels.  The test results are the means by which you should adjust your HRT dosage, NOT based on how slowly/quickly your feminization appears to be going.  Be safe!

I am a Pharmacist.

First of all, do not make any changes without talking to you doctor.

Without mentioning doses, spironolactone is always given once a day. This has to do with elimination half-life of the drug and its active metabolites.

Spironolactone is an anti androgen, but not the only one. Talk to you doctor about Finasteride.

I hope this helps.

^agreed, don't bother splitting the spiro =]

Quote from: Dani on October 05, 2016, 10:10:26 PM
Without mentioning doses, spironolactone is always given once a day.

My doctor has me taking it twice a day.

It's funny how often the words "never, always, everybody, and nobody" blow up in people's faces on this site! 

I've learned to avoid them at all costs. 

Hugs, Devlyn

My doc had me split mine after my last blood test.

My doctor also instructed me to split spiro. 

Quote from: ashadyna on October 06, 2016, 12:36:11 PM
My doctor also instructed me to split spiro.

Mine too.


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Quote from: Dani on October 05, 2016, 10:10:26 PM
Without mentioning doses, spironolactone is always given once a day. This has to do with elimination half-life of the drug and its active metabolites.

This is the only advice that needs to be mentioned in the thread.

Yes, some doctors will tell you to split the dose, they are wrong. And often suggest splitting doses for nothing more than the placebo effect.

My doctor has me on half Spiro in the morning and half in the evening. I have my blood tested every 6 months to make sure all is right.

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Quote from: kelly_aus on October 06, 2016, 05:59:46 PM
This is the only advice that needs to be mentioned in the thread.

Yes, some doctors will tell you to split the dose, they are wrong. And often suggest splitting doses for nothing more than the placebo effect.

Do you have a source for this?  I'd like to talk about this with my endo, and I'd prefer to have something stronger than "I read this on a forum."

I spoke to my doctor about splitting spiro and he said it doesn't really make a difference but if I want I can split it so I did.

Transnztal that was the feeling with my doctor as well it can be split, but one way or another doesn't mater. It has the same affect regardless theoretically. I would check with your doctor though and see what can be done, but Feminization tends to come in waves in many ways. So it may seem like no progress is being made at times although subtle things could still be occurring. Hugs
Mariah

In my humble opinion, splitting it up will only make you pee more in the evenings too.

That is actually the only reason we split mine. The endo agreed with my suggestion. since then he has included it on the script. Hugs
Mariah

Quote from: Harley Quinn on October 08, 2016, 12:23:52 PM
In my humble opinion, splitting it up will only make you pee more in the evenings too.

The half-life of Spiro requires that it be taken twice daily for steadier levels.

Quote from: KayXo on October 14, 2016, 02:30:02 PM
The half-life of Spiro requires that it be taken twice daily for steadier levels.

This. Compared to cyproterone acetate, spironolactone has a relatively short half-life.

I am a biochemist but not a doctor. You should check the blood values at a doctor. That said, I think antiandrogens are a nuisance. The feedback mechanism of the hypothalamus - pituary gland - gonads with estradio and testosterone works in a way that if estrogen is high enough, the system will downregulate testosterone production by itself, no antiandrogens needed unless maybe that feedback does not work in you or there are still issues with increased DHT. If there is still LH present , and with it T, the estrogen dosage has to be increased - preferrably with transdermal application as oral application in the required dosage may have side effects. Your doctor should be able to find the right dosage for you that allows suppression of testosterone without spiro, and THEN feminization can take off