So far as "mental changes", I don't think the changes I noticed were a result of the medications, but a relief knowing that I was on path to what I needed. I cannot say I'm more calm, more or less moody, etc. but I am no longer anxious and can focus on my goals.
Physical change? It's really hard to see. You've seen your face the same way your entire life and it's just difficult to see these small changes... It's like watching grass grow. It seems like it came out of the blue when I began to "male fail" and I still cannot even see it despite most people identifying me as a girl right away if they don't know me (if they know me, then they hear and see whatever they knew me as). I'm not 100% sure when it began, but I'd have to say the most noticeable time was while I was leaving the men's restroom at work during the 7th or 8th month. A man walked in and clearly thought he walked into the girl's bathroom by accident (as he saw me); he checked the signage and confirmed it was the men's restroom before returning with an awkward look on his face. Now, I get these looks all the time (I'm still not open about this despite the obvious changes), and I even get people telling me "This is the men's restroom! This one is for men!" and a lot of walk-in/walk-out with sign checking.