Hello, I was undergoing HRT for only 1 month and then developed two blood clots on my right calf. They have put me on a blood thinner and told me to stay off estrogen and spironolactone for a few months and be re- evaluated then to see if I can continue my treatment. I went to a hematologist for blood tests and he told me to continue with the blood thinners for 90 days. My primary HRT doctor says to wait 6 months before resuming HRT and my hematologist says that with blood thinners I don't have to worry about blood clots (deep vein thrombosis) and that I can continue with my HRT. I am confused since I am getting conflicting information and have stayed off of hormones until someone can give me more information, hopefully a different doctor as soon as I can find one that deals with transgender people. Is anyone out there taking blood thinners in conjunction with estrogen? Is it as safe as my hematologist says? I am 49. I don't drink or smoke. Has anyone gone through what I am going through? Any information on this would be greatly appreciated. By the way, there is a M to F transgender in my local support group that told me that she has been on a blood thinner and HRT for over 25 years...

What type of estrogen were you taking? Were you taking it orally or non-orally? Did you happen to take birth control pills or Premarin? Studies have shown that when bio-identical estradiol is taken non-orally, the risks of DVT are very low to negligible, even in predisposed individuals (with activated protein C resistance and protein C deficiency). As far as I know, spironolactone also has no effect on coagulation. Do you have a genetic mutation that makes it more likely that you get DVT, past incidences with it, what about family history, do you have diabetes?

I'm not a doctor so wouldn't be able to answer you. Best of luck.

I take 1 baby aspirin  a day and workout everyday to try to prevent them. My family is prone to them and I'm 15 1/2 months on hrt and never got a blood clot.

I opted for patches, since based on my readings it was the safest administration method. My family has no history of DVT and I am not aware of any health/ blood issues that would make me more prone to DVT. perhaps Perhaps I was not exercising like I should have?... Thanks for your reply.

I would ask for tests to determine if you are genetically predisposed. Did you have an operation recently? Get injured?

When I started anti-coagulation therapy (warfarin), it took several weeks to determine the proper dosage and get the INR stabilized and in the proper range. I'd been on that medication for about 10 years prior to starting HT. Good luck with it.

All the best,
--AshleyP

Yes, I am awaiting the results of my blood tests from my hematologist to see if I'm genetically predisposed/ to see if there is an underlying issue that we are not aware of. I should have them in the next few days. Lets hope for the best!

I got 3 DVTs in my right leg in 1993. They lodged in the valves of the deep saphenous vein and the circulation in that leg isn't as good as it should be and I have lymphedema. Because of that , I wear a knee high compression stocking and they put a greenfield vena cava filter in me. I've had the filter for 18 years. They put it in because they didn't want me on Coumadin for the rest of my life. I still take an aspirin on trips and if I went on e, I would take an aspirin a day. The only side effect of aspirin is that it aggravates my tinnitus.


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Ejo,

Welcome to the site.

So sorry you are experiencing this set back and additional confusion. I hope it gets straightened out soon.

I have been on HRT for about a year(52  right now). I have not experienced any problems but tend to take a low dose of aspirin fairly regularly.

I just noticed that you posted the same message in heading areas. We call that cross posting(two identical posts in more than one place) and do not allow that. It is covered in some of the links below. I merged both topics in the HRT category.

I also want to share some links with you. They are mostly welcome information and the rules that govern the site. If you have not had a chance to look through them, please take a moment:

Site Terms of Service & Rules to Live By	Standard Terms & Definitions	Post Ranks (including when you can upload an avatar)
Reputation rules	News posting & quoting guidelines	Photo, avatars, & signature images policy

Once again, welcome to Susan's. Look around, ask questions and join in.

With warmth,

Joanna

I am the same age as you, Ejo, and like Angélique, I work out 4-5 times per week and take a baby aspirin every day.
KayXo is onto a good point, too...bio-identical estradiol taken non-orally ...I inject mine.
Never had a clot.  Been doing it for several years now.

I don't work out, am not really active, don't take any blood thinner or Aspirin. I have been on injections for a couple of years with high levels of estradiol. Despite that, my clotting times have remained normal. The DVT was not necessarily due to hormones and could have happened regardless. It's difficult to establish cause and effect.

My 2 cents... (p.s. I'm not a doctor).