I only found out I'm nonbinary and partially transmale in 2013, but when I did, I began researching to catch up on gender issues and reading transgender autobiographies.
I was surprised that most-if not all- talked about an emptiness and incredible loneliness that nothing seemed to fill. even when they were married, had children, and a job they loved.
That was my case, and even though I'm currently unmarried and nontransitioning, acknowledging my male side and allowing him to be himself without suppression, as well as taking a local Thai herb, derris scandens, which relieves both dysphoria and dyslexia symptoms, has given me relief from depression/loneliness. But when I go several days without taking the herb, I can feel some of the sadness and sense of feeling lost coming back.
But perhaps those who transition and take hormones get complete relief.