So I just left my endocrinologist appointment and filled my prescriptions for a full dose of estradiol and medroxyprogesterone.  YEH me!!

I got my primary doctor to issue an order for a karyotype blood test. Just so I know.

Going to group here in St Louis tonight.

Overall it's been a pretty good day! 

Yays!  Thanks for sharing the awesomeness. 

Hugs, Devlyn

Cooool Josie,

  It sounds like a great day to me.

Hugs,
   Laurie

Congratulations.  😊

'll be interested in your before and after experiences.  You set  up  a good start, tho.

Quote from: josie76 on May 17, 2017, 06:10:35 PM
So I just left my endocrinologist appointment and filled my prescriptions for a full dose of estradiol and medroxyprogesterone.

Congrats Josie and I don't mean to rain on your parade but I feel I must mention something as regards to medroxyprogesterone acetate as I've read extensively on the matter.

This is a progestogen that can, in some people, lead to depression, anxiety and/or suicidal depression so watch out for that. In contrast to progesterone that is naturally produced in our bodies and converts to neurosteroids (allopregnanolone, pregnanolone) that have shown to be anti-depressive and anxiolytic as long as their concentrations remain stable.

Medroxyprogesterone is also weakly to moderately androgenic as it triggers androgen receptors. This is the reason estrogen's beneficial effect on lipids (HDL, LDL) is reversed by MPA. Progesterone, on the other hand, is not androgenic and has no negative impact on lipids. 

Medroxyprogesterone has been, in a large randomized trial involving ciswomen, associated with an increase in the risk of coronary heart disease and breast cancer. Other cohort studies, although less reliable, have further confirmed these findings. This is not the case with progesterone.

Lastly, it's been speculated that due to its glucocorticoid actions, it increases the risk of coagulation in women. Progesterone does not increase the risk.

Some doctors no longer prescribe medroxyprogesterone for this reason and many women refuse to take it.

I asked my endocrinologist about the medroxyprogesterone. His opinion is it works on the same cell receptors as bioidentical progesterone. He said if I want he will prescribe the bio kind. Just that he said it will run $100 month as opposed to the $6.50 I paid for this Rx.

I will watch it. If I start to feel any depressive effects I'll call him and get the other script. What are any brand names of the bioidentical progesterone? I could call around and get comparitive prices from different pharmacy's.

Quote from: josie76 on May 18, 2017, 04:26:15 PM
I asked my endocrinologist about the medroxyprogesterone. His opinion is it works on the same cell receptors as bioidentical progesterone.

As far as progesterone receptors, your endocrinologist is right. But, as far as androgen, mineralocorticoid, glucocorticoid receptors, it doesn't and this is the problem. The reason for this is because its molecule is different, modified by man so as to be more resistant to metabolization by the body. Anytime you change the structure of a molecule, you will get a different result from it. Also, medroxyprogesterone doesn't convert to neurosteroids such as allopregnanolone. There are plenty of studies explaining this in detail and any doctor prescribing either progestogen should be familiar with this.

QuoteJust that he said it will run $100 month as opposed to the $6.50 I paid for this Rx.

And this is why medroxyprogesterone is more often prescribed, sadly. Thankfully, progesterone is free for me.

QuoteWhat are any brand names of the bioidentical progesterone? I could call around and get comparitive prices from different pharmacy's.

Prometrium. You can also get it from compounding pharmacies.

I'm going to look into the information more. I don't really want to help activate the androgen receptors if I can help it either.

Quote

And this is why medroxyprogesterone is more often prescribed, sadly. Thankfully, progesterone is free for me.

Lucky girl!