Yes, it had a tendency to cause anger. Mostly repressed anger, which accrued and translates to bitterness and a feeling of having shouldered a disproportionately larger burden within a relationship, which the partner remained happily oblivious of.
When I began the relationship in 2007 I was not an angry individual, especially. But time made it build up. Up until a year ago I'd achieved a reputation for a bad temper, and for being violent to the scenery, which will no doubt follow me permanently as a footnote.
Following HRT with testosterone, I couldn't begin to explain just how much calmer and more self-aware I am. The hormones alone have gone a long way to controlling the rage generated by the feeling of being trapped and suffocated by this condition. I'm not an angry or desperate type normally - but when trapped, cornered, with no view of a way out of a bad situation, I do become destructive.