Yes. I'm at a bit over 1 year of HRT. I was started on spironolactone first. As the testosterone level dropped below the male normal range, I started experiencing periods of calm, when the 'buzzing bees' of distracting mental noise started to fade away for longer and longer periods of time.
I was started on estradiol patches at a fractional dosage after several weeks, and over the first 5 months my dosage was raised, although serum estradiol (E2) never rode past 50 pg/mL. For the past 7 months it has been at 112-115 pg/mL, in the female range, high for a woman my age (post-menopausal! Terrible reference to use, Doc!).
On the combined regimen and careful diet control, I've lost several inches of band size, 38 to 34.5". Breast development is obvious, with a 34B cup (AKA 36A, 38AA, but those wouldn't fit.) Waist has lost a bit, and hips have gained. Skin is thinner less oily, and pores on and around the nose are smaller. I've added a little fat on the cheeks, and lost a little muscle near the jaw, the Masseter muscles.
I'd say it has helped me. I've posted before/after pics in that thread.