Hi Everyone,

I am looking for someone to give me an insight why a GNRH agonist is the gold standard in Androgen Deprivation theraphy (Anti Androgen).

I understand that a GNRH agonist goes directly to the source of hormone production (i.e. Pituitary gland) and desensitizes it by sending regular pulses  it so it would stop signaling your body to stop your T production. A lot of specialist sometimes refers to it as chemical orchi.

I also understand that it's not a blocker. So I guess I am wondering what happens to the remaining T I have in my system does it attach itself to an androgen receptor? I also noticed that my skin got a bit oilier and my sleep has been a lot better.

I was on CPA before switching to Suprefact (nasal). Thanks for the feedback.

With a LhRh agonist, you are essentially reproducing the same condition as that of castrated females or males who only rely on their adrenal glands for sex hormone production, hence very little remains, too little to be worried about in regards to androgens. I actually now supplement with testosterone post-op as I find my testosterone is too little.

As regards to oilier skin since starting Suprefact, you should know the first 2-3 weeks, the pituitary gland actually goes into overdrive due to the relentless action of the agonist, eventually desensitizing so that those first few weeks, your gonads will produce increasing amounts of testosterone, hence the reason why you are experiencing such symptoms.

This anti-androgen is the gold standard as it is relatively safe and usually has very little side-effects when combined with the appropriate amount of estrogen.

Thanks Kay for the insight. I have been on Suprefact for almost half a year and the progress has been great so far. My prolactin levels went back to normal. Although, my breast has gotten a bit smaller (I think)

I tried supplementing with Prometrium but it is not for me.