What's your experience by using both anti-androgens. I'm 15 years and I'm planning to switch to Androcur because I want completely to shut down my body from producing T and then take testosterone pills and estradiol pills at least I won't pay for orchiectomy and now I'm on high dosage Spironolactone and my T levels still aren't getting into female range after two months but it is lowering testosterone. What's you experience by using both anti androgen? Also Cypro is harmful to liver, and kidneys slighty more than Spironolactone, so maybe that's why my endo won't prescribe me Cypro. I live outside USA. 

Which is best is open for discussion and dependent upon a lot of factors. I would have thought that a person your age should be on analogue blockers rather than Spiro or Androcur. The management of hormonal changes in adolescents is not simple and that is why it should be monitored by a specialist.

Taking both androcur and spiro is a waste of time and probably quite dangerous at your age, as is shutting off androgen production completely. You need androgens present not only as a sex hormone but to allow normal bone growth. You need to be very careful that you do not develop weakened bones which could result in permanent damage and possibly becoming crippled.

You really do need medical advice and care.

My little sister start around your age with lower doses of estrogen and anti androgen ( the safer the better )

Now years later she still get good result with low doses
don't be impatient about the changes it will come along specially at your age
To answer your question both do the job of blocking the T with time

spironolacton is more safe in the long term than androcur

Androcur is heavy on the body specially the liver

Both need time to low the T levels

Hi,

I have been on both Spiro for about 4 months with some effect but there was a long way to go. I was taking it over an australian summer, I found myself dehydrated regularly, cramps, going to toilet often. It wasn't very pleasant. I tried andocur and all those side effects went away and buried my testosterone in less 3 months to about 1/10 of the average female, the only side effects were not having any testoterone and everthing that comes with that. There is about 1% chance on liver damage on Andorcur and your doctor can monitor that side effect. My doctor also told me that once you on androcur you can pare back the dosage as it is very effective and that she has patients on a 1/4 to even smaller fractions of the regular dose and their testosterone remains effectively suppressed. I have just come off it for other reasons and I had to wean myself off it. I didn't really feel any difference for at leat a 1 month after completely stopping. It is quite an effective drug.

Androcur for me....but everybody is different.

Cheers,
Sarah.

Quote from: rose on August 29, 2017, 02:07:41 AM
spironolacton is more safe in the long term than androcur

This is not proven either way at this point and it appears there are some issues with spironolactone that are appearing with long term use and better science. It's also not suitable for every person to use.

QuoteAndrocur is heavy on the body specially the liver

It's not especially hard on the liver and regular blood work will show any issues long before they become serious.

A good endocrinologist should be able to halt your puberty with no long term effects whilst you decide if this right thing to do or not. Maybe you are already there, but there are limited risks pausing puberty.

A great TED talk.

I loved andro and estrogen injections at first but andro was making me really down.
I switched to spiro and I wasn't down any more.
If you look at the androcur literature it is a well documented side effect

Agreed, it is a documented side effect generally with long term use. I have struggled with depression through all of this. It is hard to tell if it has contributed. Estrogen all has documented depression risks. I think it if you are contemplating full transition including surgery it would be worth the risk given its potency and you can reduce the dose once it is full effect which presumably would reduce the risk of depression. Another idea it use Androcur first to get your testorone down use spiro to hold there.

In short consult with your doctor. It is a trial and error process.

I was on a low dose at the end and it was i was still getting down

I am a very happy and upbeat person, yes I do cry when I see or hear sad stories I am a compassionate human.

Androcur dropped my t quickly and combined with e injection my breast growth was amazing

But who wants to be depressed

Androcur is more potent. I like it a lot more. You don't need to urinate all the time like you do on spiro, too.

The only thing is, make sure your dosage is just what you need and no more. I was on more than enough and I began to feel very anxious and depressed.

Now my doctor agreed to lower it and I feel fine. It is such a strong anti-androgen that lowering the dosage seems to have had no effect.

The dehydration keeps sneaking up on my from spiro.  I woke up half an hour ago with my left leg really asleep, felt drained, had to chug 40 oz of water and a bunch of salt in a hurry, feel better now, but this is a really annoying side effect.  Last night I didn't feel that thirsty, and it's not good to drink a lot before bed time, or I wake up having to take a bunch of bathroom breaks.  It's like huge amounts of H20 and NaCl are another prescription. 

I'll have to try androcur.  The spiro isn't affecting my mood, far as I can tell.  I'm on low dose - who knows what a higher one would be like - that's a good question, do the higher doses cause even more dehydration and loss of salt?