I had monster thighs, and I mean BIG
(mostly muscles all my life) as a man.
And besides the fact it made finding clothes that fit
a challenge, it has never been an issue.
Maybe, the question is more trying to balance the
upper body. If you do a lot of upper body weightlifting
you should balance out the upper and lower body.
I've got a puny upper body, currently wearing 32B, so
there are males with big thigh, large hips and small
upper bodies. Before I transitioned, I had quite a bit
of muscles in my upper body which balanced out
my humongo lower body. I had a 40 inch torso, while now,
if I didn't have breast it would be 30 inch, you can imagine
how much muscles I lost!