How often to take any given medication depends on two things. The first is the elimination half-life of that particular drug. Short half-lives mean taking the drug more frequently. The second is does that particular drug give better results with a steady blood level or are cyclical peaks and valleys preferred.
In the case of Estradiol, oral and sublingual have relatively short half lives, so we take them several times a day. Injectable Estradiol is usually given every week or two because of the longer half-life due to the slow release of Estradiol form the oil based mixture. Patches and gels are another story, but the principle is the same. Short half life, more frequently. Long half-life less frequently.
Spironolactone has a half life of about 1 or 2 hours, but has active metabolites that last much longer. So daily dosing of Spironolactone is acceptable unless you have uncomfortable side effects right after taking Spironolactone. Then you would cut the dose in half and take it twice daily and hopefully that will reduce the side effects.
The bottom line is answered by one simple question. Are you seeing the desired results?
For HRT that feminizes, exact doses are not important. You just need to be in the normal female range for several years and just let the magic happen. There is no need to try to push or tweek your HRT.
