fat works off how it wants to, you can't target fat. You can, however, do exercises that target the waist muscles that will aid in defining the waistline. Those won't specifically help the handles, but may draw it in to make them less obvious.
I'm down to 170 from 204, guess what's left? yep, handles. I'm working on it too. I also sleep with a corset on to help push things around, except on nights when cuddling is more important. You just can't cuddle in a corset.