Quote from: Dorit on October 28, 2018, 01:23:05 AM
This is a very interesting discussion and may reflect the fact that there can be differences between what is written about a drug's side effects and what people actually experience.
In my country, Israel, Cyproterone Acetate in pills is used as the T-blocker in HRT. Those of us who have been on HRT experience increased urination. As a matter of fact, because of what you wrote about it not being a diuretic, I asked a new friend who just started HRT about four months ago, if she experienced increased urination. Her reply was yes, I have had very increased urination. Could it be the Estradiol, I doubt it?
Well, that was quite a rabbit hole..
As it turns out, it may well be the estradiol. It's known to play a part in fluid and sodium regulation, leading to increased thirst, amongst other things. Add to that the change from a primarily testosterone-driven system and I can see how estradiol could cause increased urination.
Oh, here's a question.. When you refer to "increased urination", do you mean increased volume, increased frequency or both? Increased frequency is often a function of low testosterone - and that can be achieved with estradiol alone.
There is zero scientific or medical evidence to suggest that cyproterone acetate is a diuretic. It's method of action is not one that can effect fluid regulation. I took the crap for 5 years, until I gave it up as a bad and unneeded joke a bit over 2 years ago - in consultation and agreement with my doctor. Yes, for the first year or so I did have increased urinary frequency, but that settled, along with some other things, as my body got accustomed to the new hormone balance. I'm non-op, take only estradiol now and have mid-range female T levels and a sufficient E level to keep it that way.